Two genetically identical antigen-presenting cell clones display heterogeneity in antigen processing.

APC Antigen - presenting cell

Det blir allt vanligare att man använder kroppsfrämmande material i dagens sjukvård. Materialen, som kan utgöra allt ifrån slangar, dialysmembran, katetrar, blodpumpar och proteser m.m., används för att bota patienter eller för att minska symptomen från olika typer av sjukdomar. Dessa typer av kroppsfrämmande material kallas för biomaterial eftersom de är avsedda att komma i kontakt med biologi...

Antigen-specific human T-cell clones: development of clones requiring HLA-DR-compatible presenting cells for stimulation in presence of antigen.

A method for cloning soluble antigen-specific proliferating human T lymphocytes directly from peripheral blood cells of individuals recently primed with the antigen is described. The soluble antigen was keyhole limpet hemocyanin. After expansion in liquid culture, these cells were shown to be antigen specific and to require HLA-DR-histocompatible presenting cells. Recloning of small numbers of ...

Targeting of human antigen-presenting cell subsets.

Antigen-presenting cells are a heterogeneous group of cells that are characterized by their functional specialization. Consequently, targeting specific antigen-presenting cell subsets offers opportunities to induce distinct T cell responses. Here we report on the generation and use of nanobodies (Nbs) to target lentivectors specifically to human lymph node-resident myeloid dendritic cells, demo...

Immune regulation by antigen-presenting cell EVs

Introduction Extracellular vesicles (EVs) are comprised of both microvesicles, released from the plasma membrane by shedding, and nanovesicles or exosomes, generated by reverse budding of multivesicular bodies. These different types of vesicles are characterized predominantly by their size, with exosomes ranging from 30 to 100 nm and microvesicles usually being larger than 200 nm (1–4). Althoug...

The Immunomodulatory Effect of Cyclophosphamide on Regulation of T-Cell Subsets and Antigen Presenting Cells.